![]() ![]() Students will also be encouraged to communicate with each other by e-mail for the purpose of group study sessions. At least 30 minutes of class time will be used for discussion, with interaction via teleconferencing and e-mail. Prior to the class session all students will be given a reading assignment and access to the presenters’ Microsoft® PowerPoint® slide presentation on a Harvard Web site that has been established. The televised lectures and discussion, all of which will be conducted in English, will be held from 8:00-9:30 AM (Boston time), which will be 8:00-9:30 PM of the same day at Tsinghua (in Beijing). Students at MIT/Harvard and Tsinghua will attend the same 90-minutes lecture each week. ![]() The benefits to the students of each institution in Beijing and in Boston relate to the appreciation of the similarities and differences in the way in which tissue engineering may be implemented for the solution of clinical problems ( e.g., affected by health care philosophies, economic issues, and other cultural factors). ![]() The impact of a subject taught jointly by faculty of Tsinghua University and HST relates to the very demonstration of the universality of tissue engineering principles and practice. By presenting the practice as well as the principles, students will come to appreciate the real-world difficulties encountered in translational research. Rationaleīy presenting these topics in one subject, students will have the opportunity of learning details of certain aspects of tissue engineering and be able to place them in the broader context of the overall strategic approach used to solve a clinical problem. They will have exercised this knowledge in a Term Report requiring them to select certain cells, scaffolds, cytokines, and culture conditions individually or in combination to address a specific clinical problem. Students will have learned how to apply tissue engineering principles to the solution of medical problems requiring the regeneration of tissue, and the methods for the fabrication of tissue-engineered products. Examples of tissue engineering-based procedures currently employed clinically are analyzed as case studies. Methods for fabricating tissue-engineered products and devices for implantation are taught. Discussion also addresses the influence of environmental factors including mechanical loading and culture conditions ( e.g., static versus dynamic). The rationale for employing selected growth factors is covered and the techniques for incorporating their genes into the scaffolds are examined. Methodology for the preparation of cells and scaffolds in practice is described. Differentiated cell types and stem cells are compared and contrasted for this application, as are natural and synthetic scaffolds. The principles underlying strategies for employing selected cells, biomaterial scaffolds, soluble regulators or their genes, and mechanical loading and culture conditions, for the regeneration of tissues and organs in vitro and in vivo are addressed. The principles and practice of tissue engineering (and regenerative medicine) are taught by faculty of the Harvard-MIT Division of Health Sciences and Technology and Tsinghua University, Beijing, China, (and their guest lecturers) to students of the three institutions simultaneously using the televised sessions. Note: Archived webcast lecture videos for the Fall 2008 version of this class can be found at the HST.535 Fall 2008 website. Lectures: 1 session / week, 1.5 hours / session ![]()
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